FrontLine Plus for Dogs

Fipronil Biotransformation In all species, fipronil is mainly metabolized to its sulphone derivative, which also possesses insecticidal and acaricidal properties. Fipronil is an insecticide and acaricide from the phenylpyrazole family inhibits the GABA complex, binding to the ligand-gated chloride channel blockage of pre and post synaptic transfer of chloride ions across the membrane uncontrolled activity of the central nervous system death of insects and acarids. (S)-methoprene (S)-methoprene is a synthetic compound with juvenile hormone activity required for growth and first metamorphosis & fall markedly during the final larval stage So, high levels block the normal development significant alterations in development or death of insect. Again, (S)-methoprene has a specific ovocidal action, Direct penetration of the newly laid eggshell or from absorption through the cuticle of the adult fleas. preventing flea larvae and pupae from developing, prevents contamination of treated animals with the immature stages of fleas