Boric Acid 5.75 % + Magnesium Hypophosphite Hexahydrate INN 9 % + Calcium Borogluconate 28 %
28 %
Solution
Magical 28® injection is indicated for the treatment of hypocalcaemia, hypomagnesaemia, hypophosphataemia and also indicated in the following conditions: 1. Milk fever (Parturient paresis) 2. Milk fever complex (Peri-parturient paresis) 3. Lactation tetany 4. Hypocalcaemic condition associated with late gestation or early lactation 5. Sternal recumbency (S bend of neck) 6. Hypomagnesaemic tetany (grass tetany) 7. Transit paresis/transit tetany 8. Muscle tremors & stiff gait 9. Ketosis in ruminants 10. General debility due to parasitic infestations
Calcium: Calcium is an important ion, a major component of bones and teeth and is required for maintenance of a normal cardiac rhythm, blood clotting and initiation of neuromuscular and metabolic activities. In dairy cows, short-term hypocalcaemia almost always occurs at, or soon after parturition when mammary gland secretions become more than double. The cow’s requirement for Calcium also increases. This increased demand is not always balanced by an increase in the intestinal absorption of Calcium or by the mobilization of Calcium from bone, and the concentration of ionized Calcium in the plasma may fall. Hypocalcaemic recumbency (peri-parturient paresis, milk fever complex) in sheep and cattle is a metabolic disorder which occurs as a result of hypocalcaemia, often complicated by concurrent hypophosphataemia and sometimes complicated by concurrent hypomagnesaemia. Calcium therapy is provided to correct the immediate imbalance to allow time for the homoeostatic mechanisms to adapt. An almost immediate and dramatic response follows after intravenous infusion of Calcium in all species. In ruminants, Calcium is administered by slow intravenous infusion while monitoring the heart rate and rhythm and it can be administered by subcutaneous injection behind the shoulder in two divided sites. Magnesium: Magnesium is an essential electrolyte, a co-factor in numerous enzyme systems and involved in phosphate transfer, muscle contractilities and neuronal transmission. Magnesium deficiency may occur in ruminants on lush pasture (Grass staggers) associated with heavy fertilizer application containing Nitrogen and Potash. Hypomagnesaemia may also occur in out wintered cows exposed to adverse weather conditions. Hypomagnesaemia may be a cause of sudden death in young suckled beef calves. Acute Magnesium deficiency is more commonly seen in beef cows during early lactation. Affected cattle become ataxic and excitable and collapses with tetanic convulsions of the limbs and neck. Chronic Magnesium deficiency may be associated with a decreased appetite and a reduction in milk yield. Hypomagnesaemia is often encountered in dry cows in herds with a high prevalence of milk fever (Hypocalcaemia). Hypomagnesaemic tetany (Grass tetany/Lactation tetany) is a metabolic disorder which occurs as a result of hypomagnesaemia, usually complicated by hypoglycaemia and sometimes complicated by concurrent hypophosphataemia. Treatment with mixed solutions of Calcium, Phosphorus and Magnesium is often effective and the therapeutic effect of parenteral supplementation in cases of hypomagnesaemia is temporary and dietary supplementation should be started. Phosphorus: Phosphorus is a key component in energy and protein metabolism and also is a structural part of bone. Hypophosphataemia may occur in association with parturient paresis in dairy cows but specific supplementation is not usually required. Phosphorus deficiency in the lactating cow has been associated with the development of post-parturient haemoglobinuria after the onset of acute haemolysis. More commonly, Phosphorus deficiency causes chronic hypophosphataemia, which may result in skeletal defects, lameness and low milk production. Phosphorus containing compounds may be used if animals fail to respond to Calcium therapy for parturient paresis. Chronic hypophosphataemia may occur in ruminants.
Dose
0.5 – 1
mL/kg
Frequency
q24h
Duration
2-3 days
Purpose
treatment
0.5-1.0 mL per kg body weight by subcutaneous and/or slow intravenous route. Half of the dose can be given to effect by slow intravenous injection (10-20 minutes) and the remaining half by subcutaneous injection, or the full dose can be administered by subcutaneous injection. Injection may be repeated in several hours until there is evidence of improvement. Oral route: 10 mL per liter of drinking water. Duration of treatment: 2 to 3 consecutive days
Dose
0.5 – 1
mL/kg
Frequency
q24h
Duration
2-3 days
Purpose
treatment
0.5-1.0 mL per kg body weight by subcutaneous and/or slow intravenous route. Half of the dose can be given to effect by slow intravenous injection (10-20 minutes) and the remaining half by subcutaneous injection, or the full dose can be administered by subcutaneous injection. Injection may be repeated in several hours until there is evidence of improvement. Oral route: 10 mL per liter of drinking water. Duration of treatment: 2 to 3 consecutive days
Dose
0.5 – 1
mL/kg
Frequency
q24h
Duration
2-3 days
Purpose
treatment
0.5-1.0 mL per kg body weight by subcutaneous and/or slow intravenous route. Half of the dose can be given to effect by slow intravenous injection (10-20 minutes) and the remaining half by subcutaneous injection, or the full dose can be administered by subcutaneous injection. Injection may be repeated in several hours until there is evidence of improvement. Oral route: 10 mL per liter of drinking water. Duration of treatment: 2 to 3 consecutive days
Dose
0.5 – 1
mL/kg
Frequency
q24h
Duration
3-5 days
Purpose
treatment
0.5-1.0 mL per kg body weight by subcutaneous and/or slow intravenous route. Half of the dose can be given to effect by slow intravenous injection (10-20 minutes) and the remaining half by subcutaneous injection, or the full dose can be administered by subcutaneous injection. Injection may be repeated in several hours until there is evidence of improvement. Oral route: 10 mL per liter of drinking water. Duration of treatment: 2 to 3 consecutive days
Dose
0.5 – 1
mL/kg
Frequency
q24h
Duration
2-3 days
Purpose
treatment
0.5-1.0 mL per kg body weight by subcutaneous and/or slow intravenous route. Half of the dose can be given to effect by slow intravenous injection (10-20 minutes) and the remaining half by subcutaneous injection, or the full dose can be administered by subcutaneous injection. Injection may be repeated in several hours until there is evidence of improvement. Oral route: 10 mL per liter of drinking water. Duration of treatment: 2 to 3 consecutive days
Do not use in hypermagnesaemic animals. The product should not be given by the intravenous route in toxaemic animals.