Ivermectin
N/A
Injection
Parasitin-Vet® Injection is indicated for the effective treatment and control of the following harmful species of gastrointestinal roundworms, lungworms, grubs, sucking lice, and mange mites in cattle: Gastrointestinal Roundworms (adults and fourth-stage larvae): Ostertagia ostertagi (including inhibited O. ostertagi), O. lyrata, Haemonchus placei, Trichostrongylus axei, T. colubriformis, Cooperia oncophora, C. punctata, C. pectinata, Oesophagostomum radiatum, Bunostomum phlebotomum, Nematodirus helvetianus (adults only), N. spathiger (adults only). Lungworms (adults and fourth-stage larvae): Dictyocaulus viviparous Cattle Grubs (parasitic stages): Hypoderma bovis, H. lineatum Sucking Lice: Linognathus vituli, Haematopinus eurysternus, Solenopotes capillatus Mites (scabies): Psoroptes ovis (syn. P. communis var. bovis), Sarcoptes scabiei var. bovis.
Ivermectin is a member of the macrocyclic lactone class of endectocides which have a unique mode of action. Compounds of the class bind selectively and with high affinity to glutamate-gated chloride ion channels which occur in invertebrate nerve and muscle cells. This leads to an increase in the permeability of the cell membrane to chloride ions with hyperpolarization of the nerve or muscle cell, resulting in paralysis and death of the parasite. Compounds of this class may also interact with other ligand-gated chloride channels, such as those gated by the neurotransmitter gamma-aminobutyric acid (GABA). The margin of safety for compounds of this class is attributable to the fact that mammals do not have glutamategated chloride channels, the macrocyclic lactones have a low affinity for other mammalian ligand-gated chloride channels and they do not readily cross the blood-brain barrier.
Dose
0.02 – 0
mL/kg
Frequency
q24h
Duration
1 day
Parasitin-Vet® Injection should be given only by subcutaneous injection under the loose skin in front of or behind the shoulder at the recommended dose level of 200 mcg of Ivermectin per kilogram of body weight. Each ml of Parasitin-Vet Injection contains 10 mg of Ivermectin, sufficient to treat 110 lb (50 kg) of body weight (maximum 10 mL per injection site)
Patients with a history of hypersensitivity to Ivermectin or to other macrocyclic lactones are contraindicated for this drug.